Aronsen, Lena; Ørvoll, Elin Peggy Hanne Øien; Lyså, Roy Andre; Ravna, Aina Westrheim; Sager, Georg (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-07)
Intracellular cyclic nucleotides are eliminated by phosphodiesterases (PDEs) and by ATP Binding cassette
transporters such as ABCC4 and ABCC5. PDE5 and ABCC5 have similar affinity for cGMP whereas ABCC5
has much higher affinity for cGMP compared with cAMP. Since the substrate (cGMP) is identical for these
two eliminatory processes it is conceivable that various PDE inhibitors also modulate ...